What Anti-Virus applications have known issues with Cyrious?
1. Make sure it does not have a separate firewall that is preventing connection to the database.
2. It should not be scanning files within the Cyrious folder while people are working in the system.
3. If you are backing up the database, make sure you are using Volume Shadow Copy Service.
Without the need for special configurations
For more information on how the SmartScreen filter works, see:
http://www.howtogeek.com/123938/htg-explains-how-the-smartscreen-filter-works-in-windows-8/